
Development and application of mass spectrometry based methods for high-throughput glyco(proteo)mic analysis

I obtained both my Bachelor’s (Medical Analytics) and Master’s degree (Medical Biotechnology) at the University of Pécs, Hungary, where my work focused on the analysis of clinically relevant glycosylated proteins using capillary electrophoresis hyphenated to mass spectrometry. From the very beginning of my career, I maintained a strong interest in biology and chemistry.
In 2018 – after a 3-month Erasmus internship – I moved to the Netherlands, where I am currently a PhD candidate at Leiden University Medical Center in the department of Center for Proteomics and Metabolomics under the supervision of Manfred Wuhrer and Noortje de Haan. My research project divides into two lines: technological development in the field of linkage-specific sialic acid derivatization, and clinical glyco(proteo)mics by applying cutting-edge analytical separation detection methods for high-throughput analysis.
The main challenge of glyco(proteo)mics is to understand how protein glycosylation – an abundant post-translational modification – changes in health, and altered physiological conditions, such as autoimmunity, inflammation, cancer or aging. Nevertheless, we understand that life is not just about glycans, proteins, lipids or metabolites, but all intertwined. As a team within the frames of the IMforFUTURE consortium we are pioneering the integration of these different layers of life, to which my project adds the glyco(proteo)mic layer. The ultimate goal of integrating these data is to obtain a better understanding of the mechanism of various diseases and aging.
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