Monday 8 February: Glycomics

[ Session chairs: Samira Smajlović and Tamás Pongrácz ]

14.00 – 14.15 Welcome, Jeanine Houing-Duistermaat
14.15 – 14.45 Noortje de Haan (invited speaker)
“High-Throughput Workflows Targeting the Human Glycome in the Search for Markers of Aging and Disease”
14.45 – 15.00 Contributed talk 1 – Azra Frkatović
Epigenetic regulation of the human immunoglobulin G N-glycosylation”
15.00 – 15.15 Contributed talk 2 – Arianna Landini
Same role but different actors in genetic regulation of transferrin and immunoglobulin G N-glycosylation”
15.15 – 15.30 Contributed talk 3 – Frania Zúñiga-Bañuelos
“Optimized Workflow for the In-Depth N-Glycoproteomic Analysis of Human Blood Plasma”
15.30 – 15.45 Contributed talk discussion, moderator Erdmann Rapp
15.45 – 16.00 Break
16.00 – 16.55 Poster session, with presenters arranged by presentation topic:

Developing molecular tools for studying ageing related diseases:

  • Samira Smajlović “Modulation of the HNF1A and FOXA2 genes, using CRISPR/dCas9 molecular tools, in studies of their role in glucose stimulated insulin secretion”

Statistical models for ageing:

  • Annah Muli “Use of semiparametric frailty model in analysis of survival data in twins”
  • Jacob Cancino-Romero “Prediction accuracy and variable selection for joint models of longitudinal and time-to-event data with application to the CARE75+ study”

Statistical methods for complex omics datasets (longitudinal):

  • Maarten van Schaik “Modelling high dimensional count data using random effects”
  • Sonia Dembowska “Multivariate Functional Partial Least Squares models for longitudinal OMICS datasets”
  • Minzhen Xie “Non-parametric clustering of longitudinal functional data with application to NMR spectra of 18 kidney transplant patients”

Glycosylation involved in inflammation”

  • Tamás Pongrácz “Immunoglobulin G1 Fc glycosylation as a potential early inflammation marker in COVID-19”
  • Md Shafiqur Rahman “Bisecting N-acetylglucosamine (GlcNAc) enriched IgG N-glycans are associated with chronic widespread musculoskeletal pain”
16.55 – 17.00 Group photograph, Azra Frkatović
17.00 – 17.45 Carlito Lebrilla (keynote) “Towards linking diet, ageing, and Alzheimer’s disease through glycosylation”
17.45 – 18.00 Closing

Tuesday 9 February: Ageing and Glycomics

[ Session chairs: Frania Zúñiga-Bañuelos and Azra Frkatović ]

13.55 – 14.00 Welcome
14.00 – 14.45 Gordan Lauc (keynote speaker)
“Protein glycosylation as a biomarker and functional effector of ageing and age-related diseases”
14.45 – 15.00 Contributed talk 4 – Julija Jurić 
“Effects of estradiol on biological age measured using the glycan age index”
15.00 – 15.15 Contributed talk 5 – Angga Fuady
“Association analysis of menopausal status and biological age measured using GlycanAge index from different platforms”
15.15 – 15.30 Contributed talk 6 – Juan Castillo-Fernandez
“Increased transcriptome variation and localised DNA methylation changes in oocytes from aged mice revealed by parallel single-cell analysis”
15.30 – 15.45 Contributed talk discussion, moderator Frédérique Lisacek
15.45 – 16.00 Break
16.00 – 16.45 Sylvie Ricard-Blum (keynote speaker)
“Extracellular matrix aging: a focus on the role of the lysyl oxidase family”
16.45 – 17.00 Contributed talk 7 – Lorenzo Dall’Olio
Prediction of vascular aging based on smartphone acquired PPG signals”
17.00 – 17.15 Contributed talk 8 – Iva Budimir
“Characterization of DNA methylation correlation structure in Down Syndrome”
17.15 – 17.30 Contributed talk 9 – Zhujie Gu
“Accelerated aging in Down syndrome by integrating methylation and glycomics’
17.30 – 17.45 Contributed talk discussion – moderator Hae-Won Uh
17.45 – 18.30 Break
18.30 – 19.15 Yoga session, Ana Rangel at the Sattva Institute
Ana will guide you through this Yoga session and help you to relax your mind and body after a long day of presentations.
Participants are welcome to practice with their partners, colleagues and children.
To join this session you need a Yoga mat, and a little bit of space. If a yoga mat isn’t available there is also the option of practicing on a blanket, carpet or any other anti-slippery surface.
Pregnant participants should check with their doctors if they haven’t been exercising or if they suffer from any particular condition. Ana will recommend alternative postures during the class.
19.15 – 19.30 Break
19.30 – 20.30 Anthony Newman, Publisher at Elsevier
“How to Write a Great Research Paper, and Get it Accepted by a Good Journal”
Participants will obtain an idea of the steps to take before starting to write a paper. They will also be able to plan manuscripts using the logical step sequence – not the sequence in which the paper will be read – and be made aware of what aspects of their papers editors, reviewers, and publishers look at critically, and to ensure that in taking care of these areas, their papers are much more likely to be accepted.
Issues such as dealing with referee’s comments, publishing ethics, plagiarism, will also be explained.
These insights into the publishing process will enable participants to be more confident as an author in the world of science publishing, and so should help them get their papers published more easily.

Wednesday 10 February: Ageing and Omics

[ Session chairs: Arianna Landini and Zhujie Gu ]

13.55 – 14.00 Welcome, Jeanine Houing-Duistermaat
14.00 – 14.45 Claudio Franceschi (keynote speaker)
“INFLAMMAGING: centenarians and the complex basis of human longevity”
14.45 – 15.15 Maria Giulia Bacalini (invited speaker)
“Epigenetic signature of Down Syndrome: atypical aging and beyond”
15.15 – 15.30 Break
15.30 – 16.00 Andrew Clegg (invited speaker)
The electronic Frailty Index (eFI): development, national implementation and next steps
16.00 – 16.45 Eline Slagboom (keynote speaker)
“Metabolomics markers of biological age, mortality and exceptional longevity”
16.45 – 17.00 Break
17.00 – 18.30 Panel discussion
18.30 – 19.00 Summary of posters and announcement of poster prize, Ivo Ugrina